Technology
Applications and enabling opportunities
The RheaVita Continuous Freeze-Drying Technology is compatible with all kinds of containers, like vials or dual chamber cartridges, as long as they are cylindrical. All kinds of products can be processed using the RheaVita Technology: proteins, viruses, bacteria, mRNA LNPs, ATMPs and other biopharmaceuticals.
Benefits
Conventional pharmaceutical batch freeze-drying is inherently associated with several shortcomings. RheaVita addresses those with its RheaLyo technology and brings the following value to the pharmaceutical industry:
- Time & Financial savings
- Improved quality
- Improved flexibility
Concept
The RheaLyo technology is based on spinning the vials while cooling and freezing in a controlled way using cold gas This results in a thin product layer spread over the inner vial wall. The frozen vials are subsequently dried under vacuum, where individual infrared heaters provide the radiative energy transfer for fast sublimation and desorption.
PAT
The RheaLyo technology incorporates Process Analytical Technologies (PAT) for process monitoring and control of critical process and product parameters at the level of each individual vial.
Several PAT tools, such as near-infrared spectroscopy (NIR), thermal imaging, automate cake inspection via AI image analysis can be built in.
Intellectual property
The unique RheaVita Continuous Freeze-Drying Technology is the result from an extensive model-based R&D approach. The concept and its related features are all protected by international PCT patents.
