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European Pharmaceutical Review

American Pharmaceutical Review

Literature list (click on the title to go to the download page)

A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying. Leys L., Nuytten G., Lammens J., Van Bockstal P.J., Corver J., Vervaet C., De Beer T. (2021) Pharmaceutics, 13, 2168.

Spin Freezing and Its Impact on Pore Size, Tortuosity and Solid State. Lammens J., Goudarzi N.M., Leys L., Nuytten G., Van Bockstal P.J., Vervaet C., Boone M., De Beer T. (2021) Pharmaceutics, 13, 2126.

Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying. Nuytten G., Rios Revatta S., Van Bockstal P.J., Kumar A., Lammens J., Leys L., Vanbillemont B., Corver J., Vervaet C., De Beer T. (2021) Pharmaceutics, 13, 2076.

A primary drying model-based comparison of conventional batch freeze-drying to continuous spin-freeze-drying for unit doses. Leys L., Vanbillemont B., Van Bockstal P.J., Lammens J., Nuytten G., Corver J., Vervaet C., De Beer T. (2020) European Journal of Pharmaceutics and Biopharmaceutics, 157, 97-107.

4D Micro-Computed X-ray Tomography as a Tool to Determine Critical Process and Product Information of Spin Freeze-Dried Unit Doses. Vanbillemont B., Lammens J., Goethals W., Vervaet C., Boone M., De Beer T. (2020) Pharmaceutics, 12, 430.

The Impact of Formulation Composition and Process Settings of Traditional Batch Versus Continuous Freeze-Drying On Protein Aggregation. Vanbillemont B., Carpenter J.F., Probst C., De Beer T. (2020) Journal of Pharmaceutical Sciences, 109, 3308-3318.

Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept: determination of the optimal dynamic infrared heater temperature during primary drying. De Meyer L., Lammens J., Vanbillemont B., Van Bockstal P.J., Corver J., Vervaet C., Friess W., De Beer T. (2019) International Journal of Pharmaceutics, 570, 118631.

Thermal Imaging as a Noncontact Inline Process Analytical Tool for Product Temperature Monitoring during Continuous Freeze-Drying of Unit Doses. Van Bockstal P.J., Corver J., De Meyer L., Vervaet C., De Beer T. (2018) Analytical Chemistry, 90, 13591-13599.

Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying. Brouckaert D., De Meyer L., Vanbillemont B., Van Bockstal P.J., Lammens J., Mortier S.T.F.C., Corver J., Vervaet C., Nopens I., De Beer T. (2018) Analytical Chemistry, 90, 4354-4362.

Developing a framework to model the primary drying step of a continuous freeze-drying process based on infrared radiation. Van Bockstal P.J., Corver J.*, Mortier S.T.F.C., De Meyer L., Nopens I., Gernaey K.V., De Beer T. (2018) European Journal of Pharmaceutics & Biopharmaceutics, 127, 159-170. (*Shared first authorship)

The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses. Lammens J., Mortier S.T.F.C., De Meyer L., Vanbillemont B., Van Bockstal P.J., Van Herck S., Corver J., Nopens I., Vanhoorne V., De Geest B.G., De Beer T., Vervaet C. (2018) International Journal of Pharmaceutics, 539, 1-10.

Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses. De Meyer L., Lammens J., Mortier S.T.F.C., Vanbillemont B., Van Bockstal P.J., Corver J., Nopens I., Vervaet C., De Beer T. (2017) International Journal of Pharmaceutics, 532, 158-193.

Mechanistic modelling of infrared mediated energy transfer during the primary drying step of a continuous freeze-drying process. Van Bockstal P.J., Mortier S.T.F.C., De Meyer L., Corver J., Vervaet C., Nopens I., De Beer T. (2017) European Journal of Pharmaceutics & Biopharmaceutics, 114, 11-21.

Noncontact infrared-mediated heat transfer during continuous freeze-drying of unit doses. Van Bockstal P.J., De Meyer L., Corver J., Vervaet C., De Beer T. (2017) Journal of Pharmaceutical Sciences, 106, 71-82.

Evaluation of spin freezing versus conventional freezing as part of a continuous pharmaceutical freeze-drying concept for unit doses. De Meyer L., Van Bockstal P.J., Corver J., Vervaet C., Remon J.P., De Beer T. (2015) International Journal of Pharmaceutics, 496, 75-85.