Services
RheaVita has founded the Continuous Lyo Academy as we love sharing our extensive lyophilization knowledge. Many of our courses focus on the fundamentals of freeze-drying for enthusiasts who are new to the field. For any lyophilization veterans out there, we also have more in-depth specialist courses on various aspects of our continuous freeze-drying.
Please follow our LinkedIn page and website for the upcoming Continuous Lyo Academy courses. Alternatively, you can contact us via info@rheavita.com!
RheaVita’s continuous freeze-drying expertise and services include feasibility testing for established commercialized products as well as products which are still in development. This testing often combines formulation and process development to create an optimal product with long-term stability.
For more information please contact our enthusiastic team of specialists via the button above or info@rheavita.com.
At RheaVita, we have the in-house knowledge and experience to conduct and support the formulation development of all types of drug products. We apply a synergistic approach of simultaneous formulation development and optimization of relevant process parameters, while minimizing the consumption of material. In creating the optimal development strategy, we consider the impact on both relevant critical quality attributes and also on the process performance.
For more information about RheaVita’s formulation development and optimization services, please contact our enthusiastic team of formulation specialists via the button above or info@rheavita.com.
An efficient lyophilization cycle is essential to save both time and resources, resulting in a significant reduction in operational expenses (OPEX).
To this end, RheaVita has developed first principle models to optimize the entire continuous freeze-drying process. These models use the most critical product and process parameters to calculate an optimized process with minimal material requirements. While RheaVita has developed first principle models for each step of the lyophilization process, the greatest focus is usually on primary drying because it is the most time-consuming.
For more information about RheaVita’s process development and optimization services, please contact our enthusiastic team of lyo process specialists via the button above or info@rheavita.com
You can test an online tutorial of RheaVita’s continuous primary drying model with a limited number of model input parameters. Examples of input parameters include vial dimensions, filling volume, collapse temperature (determined via freeze-drying microscopy), and chamber pressure. Based on your input, this model will compute the most efficient dynamic primary drying conditions, i.e. the IR heater energy input with respect to primary drying time, to achieve ice sublimation as quickly as possible without exceeding the critical product temperature.
