Taking Lyophilization for a Spin

Continuous freeze-drying of mRNA LNPs enables storage at higher temperatures

The pharmaceutical industry is increasingly recognizing the need to speed up and improve the lyophilization process, specifically for mRNA LNP-based vaccines and in the event of any future pandemic preparedness requirements. Thus, Thomas De Beer, Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Belgium, helped pioneer a spin freeze drying stabilization technique that could bring about an end to frozen mRNA vaccine storage – with the additional benefit of moving away from batch towards Continuous Lyophilization with a New Technique: Spin Freeze Drying continuous processing and manufacturing.

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